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Pfizer Inc fluconazole fcz sodium chloride injection
Fluconazole Fcz Sodium Chloride Injection, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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In Vitro:

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia.
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was Month XXXX Volume 0 Issue 0 10.1128/spectrum.01457-25 3 D ow nl oa de d fr om h ttp s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 23 N ov em be r 20 25 b y 18 2. ..

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was current at the time of testing, which represented the most up-to-date guideline available during the study period as shown in ( ). ..

Activity Assay:

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia.
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was Month XXXX Volume 0 Issue 0 10.1128/spectrum.01457-25 3 D ow nl oa de d fr om h ttp s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 23 N ov em be r 20 25 b y 18 2. ..

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was current at the time of testing, which represented the most up-to-date guideline available during the study period as shown in ( ). ..

Clinical Proteomics:

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia.
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was Month XXXX Volume 0 Issue 0 10.1128/spectrum.01457-25 3 D ow nl oa de d fr om h ttp s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 23 N ov em be r 20 25 b y 18 2. ..

Article Title: Identification of Candida parapsilosis sensu lato and antifungal susceptibility testing of candidemia patients in a tertiary-care hospital in Malaysia
Article Snippet: .. The in vitro antifungal activity of fluconazole (FLC), voriconazole (VRC), and posaconazole (PSC) (Pfizer, USA); caspofungin (CSF) (Merck & Co., USA); and itraconazole (ITC) and AMB (Sigma-Aldrich) was evaluated according to Clinical and Laboratory Standards Institute (CLSI) document (M27-S4, 4th edition, 2012) that was current at the time of testing, which represented the most up-to-date guideline available during the study period as shown in ( ). ..

other:


Sterility:

Article Title: Study on the mechanisms of action of berberine combined with fluconazole against fluconazole-resistant strains of Talaromyces marneffei
Article Snippet: .. Fluconazole (FLC, Pfizer Inc., Madrid, Spain) was obtained as pure powder and diluted in sterile distilled water, Berberine (BBR, Sigma–Aldrich, St Louis, MO, USA) was prepared in dimethyl sulfoxide (DMSO). .. Stock solutions were diluted in RPMI 1640 medium (Sigma Chemical Co., St. Louis, Mo.) and then serially diluted fourfold to achieve the final strength required for the test.



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The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, <t>POZ,</t> <t>ITZ,</t> <t>FCZ,</t> and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
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The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, <t>POZ,</t> <t>ITZ,</t> <t>FCZ,</t> and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
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The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, <t>POZ,</t> <t>ITZ,</t> <t>FCZ,</t> and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
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Image Search Results


The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, POZ, ITZ, FCZ, and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Prevalence and diversity of antifungal resistance in Fusarium isolates across clinical and agricultural settings in the United States

doi: 10.1128/aac.01208-25

Figure Lengend Snippet: The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, POZ, ITZ, FCZ, and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Article Snippet: FCZ was obtained from LKT Laboratory, Inc. (Cat. F4682); ITZ from Spectrum Chemical MFG.

Techniques: